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Calrithromycin used, Side effects, Dose, & more

 Calrithromycin

Brand name:- Claribid 250,500mg tabs, Clarimac 250, 500mg tabs , Synclar 250mg tab.

Clarithromycin is an antibiotic. It works by preventing synthesis of essential proteins required by bacteria to carry out vital functions. Thus, it stops the bacteria from growing, and prevents the infection from spreading.

Pharmacodynamic:-

Clarithromycin is a macrolide antibiotic whose spectrum of activity includes many gram-positive (Staphylococcus aureus, S. pneumoniae, and S. pyogenes) and gram-negative aerobic bacteria (Haemophilus influenzae, H. parainfluenzae, and Moraxella catarrhalis), many anaerobic bacteria, some mycobacteria, and some other organisms including Mycoplasma, Ureaplasma, Chlamydia, Toxoplasma, and Borrelia. Other aerobic bacteria that clarithromycin has activity against include C. pneumoniae and M. pneumoniae. Clarithromycin has an in-vitro activity that is similar or greater than that of erythromycin against erythromycin-susceptible organisms. Clarithromycin is usually bacteriostatic, but may be bactericidal depending on the organism and the drug concentration.

 Mechanism of action:- 

Clarithromycin works by inhibiting protein synthesis. This drug disrupts the production of essential proteins that bacteria need for survival and replication. It mainly leads to a decrease in bacterial growth and ultimately helps the body's immune system to eliminate the infection.

Used:- 

Clarithromycin is used in the treatment of bacterial infections. It is used in infections of tonsils, sinus, ear, nose, throat, skin and soft tissues and lungs (pneumonia).

Side Effects:-

Abdominal pain, Diarrhea, Nausea, Vomiting, Headache, Rash, Injection site phlebitis, Insomnia (difficulty in sleeping), Abnormal taste, Dyspepsia, Taste change, Abnormal liver function tests.

 Dose:-  250mg BD for 7 days ; severe cases 500mg BD up to 14 days.

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