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 ALTEPLASE (rt-PA) BRAND NAME:-ACTILYSE 50mg vial with 50ml solvent water. ALTEPLASE (rt-PA) ( recombinant tissue plasminogen activator) produced by  recombinant DNA technology from human tissue culture,it is moderately specific for fibrin- bound plasminogen,so that circulating fibriogen is lowered only by ~50% . It is rapidly cleared by liver and inactivated by plasminogen activator inhibitor-1 (PSA-1). The plasma t½ is 4-8min . Because of the short t½, it needs to be given by slow i .v . Infusion and often requires heparin co-administration . It is nonantigenic,but nausea,mild hypotension and fever may occur. It is expensive. MECHANISM OF ACTION:- Alteplase is a recombinant tissue plasminogen activator (rt-PA) that converts plasminogen to plasmin in a fibrin-dependent process. In the absence of fibrin, alteplase converts a limited amount of plasminogen. However, in the presence of fibrin clots, alteplase binds to fibrin and cleaves the arginine-valine bond at positions 560 a...