Dalfopristin 
Brand name:- Unkown
Dalfopristin is an antibiotic used with quinupristin to treat severe or life-threatening infections of vancomycin-resistant Enterococcus faecium (VREF), and skin infections caused by methicillin susceptible staphylococcus aureus or streptococcus pyogenes.
Pharmacodynamic:-
Dalfopristin is a streptogramin antibiotic, derived from pristinamycin IIA.
Mechanism of action:-
The site of action of dalfopristin is the bacterial ribosome. Dalfopristin has been shown to inhibit the early phase of protein synthesis.
Dalfopristin bind to sites located on the 50S subunit of the ribosome. Initial dalfopristin binding results in a conformational change of the ribosome, allowing for increased binding by quinupristin. A stable drug-ribosome complex is created when the two drugs are used together. This complex inhibits protein synthesis through prevention of peptide-chain formation and blocking the extrusion of newly formed peptide chains. In many cases, this leads to bacterial cell death.
Used:-
Used in the treatment of multiple sclerosis (MS). It helps to improve walking ability and walking speed in people with multiple sclerosis.
Side effects:-
Influenza, Viral infection, Anxiety, Vertigo, Palpitations, Breathlessness, Vomiting
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