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 Candesartan Brand name:- Candesartan 4,8,10mg tab, Candilong,candestan 4,8 mg tabs. Candesartan has the highest affinity for the AT¹ receptor and produces largely insurmountable antagonism , probably due to slow dissociation. Elimination occurs by both hepatic metabolism and renal excretion with a t½ of 8 -12 hours: action lasts 24hours . Pharmacodynamic:-  Candesartan cilexetil is an ARB prodrug that is rapidly converted to candesartan, its active metabolite, during absorption from the gastrointestinal tract. Candesartan confers blood pressure lowering effects by antagonizing the hypertensive effects of angiotensin II via the RAAS. RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from granular cells of the juxtaglomerular apparatus in the kidneys. Renin cleaves circulating angiotensinogen to angiotensin I, which is cleaved by angi...