BETHANECHOL BRAND NAME:- Duvoid, Myotonachol (Glenwood), Urecholine (Merck Frosst) and Urocarb (Hamilton). BETHANECHOL is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action. Bethanechol is a muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention. PHARMACODYNAMIC:- Bethanechol is selective for muscarinic receptors and has little to no impact on nicotinic receptors.1 The charged quaternary amine in the structure of bethanechol prevents it from crossing the blood-brain barrier which minimizes central nervous system related adverse effects. MECHANISM OF ACTION:- Bethanechol is a direct muscarinic agonist and stimulates the parasympathetic nervous system by ...
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