webmedi.blogspot.com

 ARTESUNATE - MEFLOQUINE (AS/MQ) BRAND NAME:- FALCIGO PLUS KIT . ARTESUNATE - MEFLOQUINE (AS/MQ) is an antimalarial and artemisinin Derivatives drug.  This is the standard and most extensively used ACT (ARTEMISININ -BASED COMBINATION THERAPY) in Thailand, Myanmar and other Southeast Asian countries as well as south America and Africa. It was found highly effective and well tolerated in uncomplicated falciparum malaria. However,many areas in far East already have MQ - resistant p.f., but by combining with AS , further spread of MQ resistance was checked. Nevertheless, some of them have switched over to alternative ACTs . In INDIA AS/MQ has been Used to a limited extent,but small studies have shown ~100% efficacy. A kit with separate AS and MQ tablets is available and a FDC formulation has been approved. USED:- treatment of malaria. SIDE EFFECTS:- MQ NEED TO BE WATCHED FOR . DOSE:- artesunate 100mg BD(4mg/kg/day) for 3 days + mefloquine 750mg (15mg/kg) on 2nd day and 500mg (10mg...

 ARTESUNATE + SULFADOXINE + PYRIMETHAMINE (AS-S/P) BRAND NAME:- ZESUNATE kit, MASUNATE kit,FALCIART kit  ARTESUNATE + SULFADOXINE + PYRIMETHAMINE (AS-S/P) ia an antimalarial Drug, groups of artemisinin Derivatives. This ACT has been adopted as the first line drug for uncomplicated falciparum malaria under the 'National antimalarial Drug policy ' of India,and has replaced CQ throughout the country. This does not imply that it is the most effective/ best ACT , because it is not effective against multidrug - resistance strains which are non responsive to S/P . However, treatment failures with AS-S/P ACT are mostly restricted to Northeast areas bordering Myanmar; while in rest of INDIA so far this ACT appears to be working satisfactorily with > 96% success rate. As such ,NVBDCP continues to use AS-S/P ACT as the first line therapy, including that during 2nd 3rd trimester of pregnancy. This ACT appears to produce fewer side effects than artesunate/ mefloquine. Private clinic, ho...

 ARTEMETHER + LUMEFANTRINE (1:6) BRAND NAME:-COARTEM ,COMBITHER,LUMETHER  (ARTEMETHER 80mg + LUMEFANTRINE 480mg ) ARTEMETHER LUMEFANTRINE is an antimalarial Drug,use in artemisinin -based combination therapy (ACT) . LUMEFANTRINE is an orally active,high efficacy, long - acting erythrocytic schizontocide, related  chemical . LUMEFANTRINE is highly lipophilic;  LUMEFANTRINE is used only in combination with ARTEMETHER,as  FDC tablets . The two components protect each other from plasmodial resistance. MECHANISMS OF ACTION:-  Long - acting erythrocytic schizontocide, related chemically and in mechanism of action to halofantrine and MQ . Additionally , nucleic acid and Protein synthesis of parasite is affected. Like the others,vivax hypnozoites are not affected. LUMEFANTRINE is highly lipophilic; absorption starts after 2 hours of ingestion and peaks at 6-8 hours. Antimalarial action is slower than CQ . plasma proteins binding is 99% , and it is metabolized predo...