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 Ciclesonide Brand name:- Ciclez 80ûg and 160ûg per metered inhaler. Ciclesonide is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies. Pharmacodynamic:-  Ciclesonide is a pro-drug that is enzymatically hydrolyzed to a pharmacologically active metabolite, C21- desisobutyryl- ciclesonide (des- ciclesonide or RM1) following intranasal application. Des- ciclesonide has anti-inflammatory activity with affinity for the glucocorticoid receptor that is 120 times higher than the parent compound. The precise mechanism through which ciclesonide affects allergic rhinitis symptoms is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in allergic inflammation. Mechanism of action:-  ...