webmedi.blogspot.com

 ACENOCOUMAROL ( NICOUMALONE ) BRAND NAME:- ACITROM,1,2,3 mg tabs. Acenocoumarol is an anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction. Generic Name Acenocoumarol DrugBank Accession Number DB01418 Background. Pharmacodynamic:-  Acenocoumarol inhibits the reduction of vitamin K by vitamin K reductase. This prevents carboxylation of certain glutamic acid residues near the N-terminals of clotting factors II, VII, IX and X, the vitamin K-dependent clotting factors. Glutamic acid carboxylation is important for the interaction between these clotting factors and calcium. Without this interaction, clotting cannot occur. Both the extrinsic (via factors VII, X and II) and intrinsic (via factors IX, X and II) are affected by acenocoumarol. Mechanism of action:-  Acenocoumarol inhibits vitamin K reductase, resulting in depletion of the reduced for...