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 APOMORPHINE BRAND NAME:-Zyprima 2-3mg ,SL tablet etc. APOMORPHINE is a semisynthetic derivative of morphine; acts as a dopaminergic agonist on the CTZ . Used to treat hypomobile "off" episodes of advanced Parkinson's disease.  PHARMACODYNAMIC:-  It is a semisynthetic derivative of morphine; acts as a dopaminergic agonist on the CTZ. Injection i.m./s.c in a dose of 6 mg ,it promptly (within 5 min) induced vomiting. It should not be used if resipration is depressant actions. Oral use of APOMORPHINE is not recommended because the emetic dose is larger ,slow to act and rather inconsistent in action. Apomorphine has a therapeutic effects in Parkinosonism,but is not used to side effects. MECHANISM of ACTION:- Apomorphine is a non-ergoline dopamine agonist with high binding affinity to dopamine D2, D3, and D5 receptors. Stimulation of D2 receptors in the caudate-putamen, a region of the brain responsible for locomotor control, may be responsible for apomorphine's action. Ho...