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 ARTEMETHER + LUMEFANTRINE (1:6) BRAND NAME:-COARTEM ,COMBITHER,LUMETHER  (ARTEMETHER 80mg + LUMEFANTRINE 480mg ) ARTEMETHER LUMEFANTRINE is an antimalarial Drug,use in artemisinin -based combination therapy (ACT) . LUMEFANTRINE is an orally active,high efficacy, long - acting erythrocytic schizontocide, related  chemical . LUMEFANTRINE is highly lipophilic;  LUMEFANTRINE is used only in combination with ARTEMETHER,as  FDC tablets . The two components protect each other from plasmodial resistance. MECHANISMS OF ACTION:-  Long - acting erythrocytic schizontocide, related chemically and in mechanism of action to halofantrine and MQ . Additionally , nucleic acid and Protein synthesis of parasite is affected. Like the others,vivax hypnozoites are not affected. LUMEFANTRINE is highly lipophilic; absorption starts after 2 hours of ingestion and peaks at 6-8 hours. Antimalarial action is slower than CQ . plasma proteins binding is 99% , and it is metabolized predo...

 ARTEMETHER BRAND NAME:- PLAUTHER,LARITHER, MALITHER 80mg inj(in 1ml arachis oil). ARTEMETHER is an antimalarial Drug ,class of sesquiterpine lactones group and artemisinin Derivatives drug.  IT is a lipid -soluble and is administered orally or i.m., but not i.v. Absorption after oral as well as i.m. dosing is slower talking 2-6 hours . It undergoes substantial first pass metabolism and is converted to DNA . Extensive metabolism and is converted to DNA.Extensive metabolism by CYP3A4 yield a variable t½ of 3-10hours. PHARMACODYNAMICs:-  ARTEMETHER is metabolized into the active metabolite metabolite dihydroartemisinin. The drug works against the erythrocytic stages of  P. falciparum  by inhibiting nucleic acid and protein synthesis. Artemether is administered in combination with lumefantrine for improved efficacy. Artemether has a rapid onset of action and is rapidly cleared from the body. It is thought that artemether provides rapid symptomatic relief by reducin...