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 BISHOSPHONATES BRAND NAME:- NOT AVAILABLE. BISPHOSPHONATES (BPNs) are analogue of pyrophosphate: carbon atom replacing oxygen in the P-O-P skeleton. They inhibits bone resorption and have recently attracted considerable attention because of their ability to prevent osteoporosis in addition to their usefulness in metabolic bone disease and hypercalcaemia. They are the most effective antiresorptive drugs . Chronologically and according to potency, the BPNs can be grouped into 3 generation. The first generation compounds have simpler side chains ,are the least potent and seldom Used now. The second and third generation compounds have an amino or nitrogenous ring substitution in the side chain, are more potent,have higher efficacy and additional mode of action. PHARMACOKINETICS:- BISPHOSPHONATES that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapid...