webmedi.blogspot.com

BROMOCRIPTINE BRAND NAME:-   PROCTINAL, SICRIPTIN,PARLODEL,1.25,2.5mg tabs, ENCRIPT 2.5,5mg tabs. BROMOCRIPTINE is synthetic ergot derivative 2- bromo- alpha - ergocryptine is a potent dopamine agonist; most of its actions are based on this property. It has greater action on D2 receptors, while at certain dopamine sites in the brain it acts as a partial agonist or antagonist of D1 receptors. It is also a weak alpha adrenergic blocker but not an oxytocic . PHARMACOKINETICS:- Only ⅓ of an oral dose of bromocriptine is absorbed; bioavailability is further lowered by high first pass metabolism in liver . Even then ,it has higher oral: parenteral activity ration than ergotamine. Metabolites are excerted mainly in bile. Its plasma t½ is 3-6hours. MECHANISM OF ACTION:-  BROMOCRIPTINE has greater action on D2 receptors, while at certain dopamine sites in the brain it acts as a partial agonist or antagonist of D1 receptors. It is also a weak alpha adrenergic blocker but not an oxy...