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ATAZANAVIR (ATV)

 ATAZANAVIR(ATV) BRAND NAME:- ATAZOR 100,150,200,300mg caps. ATAZANAVIR is an antiviral and retroviral protease inhibitors (PIs) drug. An aspartic protease enzyme enclosed by HIV is involved in the production of structural proteins and enzymes of the virus from the large viral polyprotein synthesized in the infected cell. The polyprotein is broken into various functional components by the protease enzyme. It acts at a let step in HIV replication, i.e maturation of the new virus particles when the RNA genome acquires the core proteins and enzymes. PHARMACOLOGICAL & MECHANISM OF ACTION:- This PIs  is administered with light meal which improve absorption, while acid suppressant drugs decrease it's absorption. ATV is primarily metabolized by CYP3A4, which is also moderately inhibited by it. Bioavailability and efficacy of ATV is improved by combining with RTV . The t½ is 6-8 hours. Dyslipidaemia and other metabolic complicated are minimal with ATV , but jaundice occurs in some...