Chlorhexidine Brand name:- Savlon or etc. A power, nonirritating,cationic antiseptic that disrupts bacterial cell membrane. A secondary action is denaturation of microbial proteins. It is relatively more active against gram - positive bacteria. Like hexachlorophene it persists on the skin. Mechanics of action:- At physiologic pH, chlorhexidine salts dissociate and release the positively charged chlorhexidine cation. The bactericidal effect is a result of the binding of this cationic molecule to negatively charged bacterial cell walls. At low concentrations of chlorhexidine, this results in a bacteriostatic effect; at high concentrations, membrane disruption results in cell death. Pharmacodynamic:- Chlorhexidine is a broad-spectrum antimicrobial with demonstrated activity against both gram-positive and gram-negative bacteria, yeasts, and viruses.2 Antimicrobial activity is dose-dependent - chlorhexidine is bacteriostatic at lower concentrations (0.02%-0.06%) and b...
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