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 ATOVAQUONE BRAND NAME:- MEPRON  ATOVAQUONE is an antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria.  PHARMACOLOGY & MECHANISM OF ACTION:- This synthetic naphthoquinone is a rapidly acting erythrocytic schizontocide as well as active against preerythrocytic stage of P.falciparum and other plasmodia . Pneumocystis jiroveci and Toxoplasma gondii are also susceptible to atovaquone . It collapses plasmodial mitochondrial membrane and interferes with ATP production. Proguanil potentiates its antimalarial action and prevent emergence of resistance.  Atovaquone is a competitive inhibitor of ubiquinol, specifically inhibiting the mitochondrial electron transport chain at the bc1 complex. Inhibition of bc1 activity results in a loss of mitochondrial function. Several metabolic enzymes are linked to the mitochondrial electron transport chain via ubiquinone...