webmedi.blogspot.com

 CYCLOSPORINE BRAND NAME:-  IMUSPORIN 25,50,100mg soft gelatin capsules. , Sandimmun neoral, Panimun Bioral 25,50,100mg caps ., Sandimmun, Panimun 100mg/ml inj in 1ml ,5ml, 50 ml vial. PHARMACOKINETICS:- Ciclosporin is a cyclic peptide of 11 amino acids; it contains a single D-amino acid, which is rarely encountered in nature. Unlike most peptides, ciclosporin is not synthesized by ribosomes. Ciclosporin is highly metabolized in humans and animals after ingestion. The metabolites, which include cyclosporin B, C, D, E, H, and L,have less than 10% of ciclosporin's immunosuppressant activity and are associated with higher kidney toxicity.Individual ciclosporin metabolites have been isolated and characterized but do not appear to be extensively studied. PHARMACODYNAMIC:- Cyclosporine exerts potent immunosuppressive actions on T cells, thereby prolonging survival following organ and bone marrow transplants. This drug prevents and controls serious immune-mediated reactions including...