Citicoline Brand name:- Citilin, Citinova 500mg tab, 500mg/2ml injection., Strolin 500mg tab, Strocit, Ceham ,Citistar. Citicoline, also known as cytidine diphosphate-choline or cytidine 5 '-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in cell membranes. Citicoline is naturally occurring in the cells of human and animal tissue, in particular the organs. Pharmacodynamic:- Citicoline increased choline acetyltransferase expression for phosphatidylcholine synthesis after hypoglycemia. These findings suggest that neuronal membrane stabilization by citicoline administration can save neurons from the degeneration process after hypoglycemia, as seen in several ischemia studies. Pharmacokinetics:- Administration of 300mg dose to healthy adults shows nearly complete absorption, with less than 1% of excretion in feces . The main route of excretion was found to be via a respiratory route, with signifi...
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