CYPROHEPTADINE BRAND NAME:- PRACTIN , CIPLACTIN 4mg tab ., 2mg/5ml syrup. CYPROHEPTADINE is a combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome. PHARMACODYNAMIC:- Cyproheptadine has been observed to antagonize several pharmacodynamic effects of serotonin in laboratory animals, including bronchoconstriction and vasodepression, and has demonstrated similar efficacy in antagonizing histamine-mediated effects. The reason for its efficacy in preventing anaphylactic shock has not been elucidated, but appears to be related to its anti-serotonergic effects. PHARMACOKINETICS:- Cyproheptadine is well-absorbed following oral ingestion, with peak plasma levels occurring after 1 to 3 hours.Its terminal half-life when taken orally is approximately 8 hours. MECHANISM OF ACTION:- Cyproheptadine appears to exert its antihistamine and antiserotonin effects by competing wi...
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