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 ACYCLOVIR BRAND NAME:- ZOVIRAX 200mg tab,250mg /vial for i.v inj ; CYCLOVIR 200mg tab , 5% skin cream; HEPREX 200mg tab, 3% eye oint, 5% skin cream; OCUVIR 200,400,800mg tab,3% eye oint,ACIVIR DT 200,400,800mg tab . ACIVIR EYE 3%oint. ACYCLOVIR the deoxiguanosine analogue antiviral drug requires a virus specific enzyme for conversion to the active metabolite that inhibits DNA synthesis and viral replication.  ACYCLOVIR is preferentially taken up the virus infected cells. Because of selective generation of the active inhibitors in the virus infected cells and it's greater inhibitory effects on viral DNA synthesis, ACYCLOVIR has low toxicity for host cells : a several hundred -fold chemotherapeutic index has been noted. ACYCLOVIR is active only against herpes group of viruses; HSV-1 is most sensitive followed by HSV-2 >VZV =EBV, while CMV is practically not affected. HSV and VZV have been found to develop resistance to acyclovir during therapy;the former primarily due to mut...