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 ARTESUNATE -PYRONARIDINE(1:3) BRAND NAME:-   ZUNATE KIT OR etc. ARTESUNATE -PYRONARIDINE is an antimalarial and artemisinin Derivatives drug.  Pyronaridine is a water soluble naphthyridine Mannich base erythrocytic schizontocide with high efficacy and mechanism of action similar to CQ ,that has been used in China for -40 years. It is active against both CQ- sensitive and CQ- resistance P. falciparum and other malarial species. The onset of action is slower and duration long . It is concentration in RBCs and metabolized with a terminal t½ for 7days. Weak analgesic antipyretic action is produced at higher doses. Clinically efficacy of artesunate -PYRONARIDINE FDC (dose 1:3) has been tested in falciparum malaria in china, Thailand and Africa with > 95% success and no recrudescence in 28days. Multidrug resistant P.falciparam and P . Vivax also respond. Clinical trials have been completed in India 🇮🇳 with > 95% cure rates. Artesunate -PYRONARIDINE is well tolerat...