webmedi.blogspot.com

 ASTEMIZOLE BRAND NAME:- Hismanal  ,Acipax, Alestol , Astem  ASTEMIZOLE are the earliest second generation H1 antihistamine drug. It treats allergy symptoms such as itching, swelling, and rashes by blocking the effects of a chemical messenger (histamine) in the body.  It has anticholinergic and antipruritic effects. PHARMACODYNAMIC:- Astemizole is a second generation H1-receptor antagonist. It has anticholinergic and antipruritic effects.It does not significantly cross the blood brain barrier and therefore does not cause drowsiness or CNS depression at normal doses. Several studies  have shown high permeability and high binding to protein folds associated with Alzheimer's. MECHANISM OF ACTION:-  Astemizole competes with histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of astemizole to H1-receptors suppresses the formation of edema, flare, and pruritus resulting from histam...