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 ALISKIREN BRAND NAME:- RASILEZ 150mg tab; RASILEZ-HC : along with hydrochlorothiazide ALISKIREN is a direct renin inhibitors (DRIs) are the latest class of RSA inhibitory drugs, of which only one member Aliskiren has become available for the treatment of cardiovascular and renal diseases in which ACE inhibitors and ARBs are currently used.  MECHANISM OF ACTION:- Aliskiren is a nonpeptide which binds selectively to the catalytic site of renin and competitively blocks the access of angiotensinogen to this site –> Ang I is not produced and the chain of RSA is interrupted. While the concentration of renin in plasma is increased by feed back, the plasma renin activity (PRA) is  decreased. Ang I and II levels fall. Aliskiren causes fall in BP which is more marked in the Na+ depleted subjects with High basal PRA . Similar to ACE inhibitors, plasma Aldosterone levels are lowered accompanied by mild natriuresis and a tendency to K+ retention. The antihypertensive  efficac...