Cholera vaccine Brand name:- Dukoral,ShanChol . Cholera Vaccine (Inactivated) is an inactivated vaccine (made from a dead bacteria). It helps develop immunity by forming antibodies, which are proteins that protect against infection caused by cholera bacteria. Pharmacodynamic:- It is a suspension of phenol/formation killed inaba and ogawa strains of V. Cholera,each ml containing 8× 10⁹ organisms in 5,10,30 ml vials. Immunity, sufficient to prevent clinical disease, is produced only in 50% of those innoculated , and lasts 6 months or so —sufficient to tide over an epidemic. Cholera innoculation during congregation (melas) has not reduced the incidence of the disease ( because it takes 2-3 weeks for immunity to develop): this practice has been discontinued. It also does not prevent carrier state. Transient local soreness,low grade fever,ashes and pains lasting 1-2days are common. Neurological complication are rare. mechanics of action:- It' s contains a live a...
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