webmedi.blogspot.com

 BIVALIRUDIN BRAND NAME:-  Angiomax ,Angiox BIVALIRUDIN is a direct thrombin inhibitor . It is a smaller peptide prepared synthetically which has action, However,its action is slowly reversible due to cleavage of its peptide bonds by thrombin itself. Used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention.  PHARMACODYNAMIC:- Coagulation times return to baseline approximately 1 hour following cessation of bivalirudin administration. Bivalirudin mediates an inhibitory action on thrombin by directly and specifically binding to both the catalytic site and anion-binding exosite of circulating and clot-bound thrombin. The action of bivalirudin is reversible because thrombin will slowly cleave the thrombin-bivalirudin bond which recovers the active site of thrombin. MECHANISM OF ACTION:- Bivalirudin directly inhibits thrombin by specifically binding both to the catalytic site and to the anion-binding exosite of circulati...