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 Chloramphenicol Brand name:- Chloromycetin,Enteromycetin,Paraxin 250,500mg cap.  Chloramphenicol was initially obtained from streptomyces venezuelae in 1947 . It was soon synthesized chemically and the commercial product now is all synthetic. It is a yellowish white crystalline solid, aqueous solution is quite stable, stands boiling, but needs protection from light. The nitrobenzene moiety of chloramphenicol is probably responsible for the antibacterial activity as well as its intensely bitter taste. Mechanicsm of action:- Chloramphenicol inhibits bacterial protein synthesis by interfering with 'transfer' of the elongating peptide chain to the newly attached aminoacyl-tRNA at the ribosome- mRNA complex. It specifically attaches to the 50S ribosome near the acceptor (A) site and prevents peptide bond formation between the newly attached aminoacid and the nascent peptide chain without interfering with the aminoacyl-tRNA attachment to the 30S ribosome (the step blocked by tetrac...