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 BENIDIPINE BRAND NAME:- CARITEC 4,8mg tab, inzit,BENITOWA, Beniopack. BENIDIPINE is a long - acting DHP that owes its long duration of action to slow dissociation from the DHP receptor on the smooth muscle cells. Marketed only in India and Japan,it is indicated in hypertension and angina pectoris. PHARMACODYNAMIC:-  Benidipine reduces systolic and diastolic blood pressure as well as to present decreases in heart rate pulse after treatment. It is reported also a decrease urinary protein excretion and serum triglycerides. Different studies have shown benidipine anti-oxidative activity, stimulation of NO production, suppression of adhesion molecules expression, stimulation of osteoblast differentiation, suppression of the proliferation of vascular smooth muscle cells and mesangial cells, as well as myocardial protection. The enhancement of NO production is associated with the cardioprotective and anti artheriosclerotic effects of benidipine. MECHANISM OF ACTION:- Benidipine is a...