ACARBOSE BRAND NAME:- GLUCOBAY 50,100mg tabs ,ASUCROSE, GLUCAR 50mg tabs. ACARBOSE is a miscellaneous antidiabetic ,class of alpha -Glucosidase inhibitors drug. ACARBOSE is a mild antihyperglycaemic and not a hypoglycaemic . PHARMACOLOGICAL & MECHANISM OF ACTION:- It is a complex oligosaccharide which reversibly inhibits alpha- glucosidases, the final enzyme for the digestion of carbohydrates in the brush border of small intestine mucosa . It slows down and decrease digestion and absorption of polysaccharides (strach,etc.) and sucrose. In addition,GLP-1 release is promoted which may contribute to the effect. Postprandial glycaemia is reduced without significant increase in insulin levels. Regular use lowers HbA1c modestly (by 0.4-0.8%) ,but change in body weight and lipid level is minimal. The stop- NIDDM trail (2002) has shown that long- trem ACARBOSE treatment in prediabetics reduced occurance of type 2DM as well as hypertension and cardiac disease. In diabetics,it red...
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