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 APRACLONIDINE BRAND NAME:- ALFADROPS DS 1% eyedrops  APRACLONIDINE  also known as iopidine ,   It is an alpha2-adrenergic agonist. An alpha adrenergic agonist used to treat raised intraocular pressure.  PHARMACODYNAMIC:- Apraclonidine is a sympathomimetic. It works by decreasing the production of aqueous humour (fluid in the eye), thereby lowering the increased eye pressure.  Apraclonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. MECHANISM OF ACTION:- It is a polar clonidine congener which does not cross blood - brain barrier,but applied topically (0.5-1%) it lowers i.o.t. by - 25% . It decreases aqueous production by primary alpha2 and subsidiary alpha1 action in the ciliary body. Apraclonidine is a relatively selective alpha2 adrenergic receptor agonist that stimulates alpha1 receptors t...