BISACODYL BRAND NAME:- DULCOLAX 5mg,10mg tab & suppository,CONLAX 5mg ,10mg suppository,BIDLAX-5 5mg tab. BISACODYL is a laxative. It works by increasing the movement of the intestines, thereby facilitating the passage of stool. It also helps clean out the intestines prior to medical procedures or examinations. PHARMACODYNAMIC:- They are partly absorbed and reexcreted in bile. The enterohepatic circulation is greater in case of phenolphthalein which can produce protracted action. Bisacodyl is activated in the intestine by deacetylation . The primary site of action of diphenylmethanes is in the colon where they irritate the mucosa , produce mild inflammation and increase secertion. One or two semiformed motions occurs after 6-8 hours. MECHANISM OF ACTION:- Bisacodyl works by stimulating enteric neurons to cause peristalsis, i.e., colonic contractions. It is also a contact laxative; it increases fluid and salt secretion. The action of bisacodyl on the small int...
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