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Showing posts with the label Dettol antisepsis

Chloroxylenol Uses, Side Effects, and More

 Chloroxylenol Brand name:- Dettol,Dettolin 1% with menthol 0.45% It has a phenol coefficient of 70; does not cosgulate proteins,is noncorrosive, nonirritating  to intact skin, but efficacy is reduced by oraganic matter. It is poorly water soluble; the commercial 4.8% solution (Dettol) is prepared in 9% terpinol and 13% alcohol. Pharmacodynamic:- Chloroxylenol is a substituted phenol which has been widely used for many years as an ingredient of antiseptic and disinfectant products intended for external use . It is known to be bactericidal in low concentration to a wide range of Gram positive and Gram negative bacteria . Mechanics of action:-  As a phenol antiseptic, it is believed that the hydroxyl -OH groups of the chloroxylenol molecule binds to certain proteins on the cell membrane of bacteria, and disrupts the membrane so as to allow the contents of the bacterial cell to leak out 1. This allows chloroxylenol to enter the bacterial cell to bind further with more protei...