Clavulanic acid Brand name:- Agumentine, Amoxyclav, Clavam, Mahacef cv 625. Clavulanic acid is a β- lactam drug that functions as a mechanism-based β -lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β -lactamase, which otherwise inactivates most penicillins. It is mostly used with amoxycillin combination. Amoxycillin + Clavulanic Acid is a combination of two medicines: amoxycillin and Clavulanic Acid. Amoxycillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Clavulanic Acid is a beta- lactamase inhibitor which reduces resistance and enhances the activity of amoxycillin against bacteria. Pharmacodynamic:- Clavulanic acid inactivates some beta-lactamase enzymes that are produced by bacteria, therefore preventing enzymatic destruction of amoxicillin. This help...
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