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 ASPARAGINASE(L-ASPARAGINASE),(L-ASPase) BRAND NAME:- LEUNASE,HOILASP 10,000 KU per vial inj .Elspar. Asparaginase  is an  enzyme  that is used as a medication and in  food manufacturing . As a medication ,L-ASPase is an ANTI-CANCER and miscellaneous cytotoxic class of drug. Is used in treatment of acute lymphocyte leukaemia (ALL). It  worked by starving tumer cells of needed nutrents and slowing cell growth.  PHARMACOLOGICAL & MECHANISM OF ACTION:- This is enzyme was introduced on the basis of a different observed between normal cells and those from childhood Lymphoblastic leukaemia,viz . The leukaemia cells were found to be deficient in L- ASPARAGINASE synthase enzyme and depended on the supply of L-asparagine from the medium. The enzyme L-ASPase (from E.coli.) degrades L- ASPARAGINe to L - aspartic acid , depriving the leukaemia cells of an essential metabolite, and causes cell death.  L-ASPase is a component of regimen for inducing remissi...