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 BORTEZOMIB BRAND NAME:- EGYBORT 3.5mg vial for inj  BORTEZOMIB is an anti-cancer medication used to treat multiple myeloma and mantle cell lymphoma.This includes multiple myeloma in those who have and have not previously received treatment. It is generally used together with other medications. It is given by injection . PHARMACODYNAMIC:- After subcutaneous administration, peak plasma levels are ~25-50 nM and this peak is sustained for 1-2 hrs. After intravenous injection, peak plasma levels are ~500 nM but only for ~5 minutes, after which the levels rapidly drop as the drug distributes to tissues (volume of distribution is ~500 L). Both routes provide equal drug exposures and generally comparable therapeutic efficacy. Elimination half life is 9–15 hours and the drug is primarily cleared by hepatic metabolism. The pharmacodynamics of bortezomib are determined by quantifying proteasome inhibition in peripheral blood mononuclear cells taken from people receiving the drug.  ...