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 BLEOMYCIN   BRAND NAME :- BLEOCIN, BELCAM injection  BLEOMYCIN is a mixture of closely related glycopeptide antibiotics having potent antitumour activity. Used to treat various malignancies, including head and neck malignancy, lymphoma, and testicular tumors, among others. PHARMACOLOGY :- BLEOMYCIN is a glycopeptide antibiotics having antitumour activity. It chelates copper or iron , produces superoxide ions and intercalates between DNA strands —causes chain scission and inhibits repair. It is selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Bleomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. The antibiotic antitumor drugs are cell cycle-...