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  BISOPROLOL BRAND name:- CONCOR ,CORBIS 5mg tab  BISOPROLOL is a Cardioselective Beta blockers lacking intrinsic sympathomimetics activity; suitable for once daily administration in angina, hypertension and CHF. PHARMACODYNAMIC:- Bisoprolol decreases heart rate (chronotropy), decreases contractility (inotropy), and reduces blood pressure. The results of various clinical studies indicate that bisoprolol reduces cardiovascular mortality and all-cause mortality in patients with heart failure and decreased cardiac ejection fraction (EF). MECHANISM of action:- Bisoprolol is cardioprotective because it selectively and competitively blocks catecholamine (adrenaline) stimulation of β1 adrenergic receptors (adrenoreceptors), which are mainly found in the heart muscle cells and heart conduction tissue (  cardiospecific )  but also found in juxtaglomerular cells in the kidney. It works by relaxing blood vessels and slowing heart rate to improve and decrease blood pressure. Hig...