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 BRADYKININ BRAND NAME:- UNKNOWN. BRADYKININ  is a peptide that promotes inflammation. It causes arterioles to dilate (enlarge) via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor and makes veins constrict, via prostaglandin F2, thereby leading to leakage into capillary beds, due to the increased pressure in the capillaries. Bradykinin is a physiologically and pharmacologically active peptide of the kinin group of proteins, consisting of nine amino acids.  MECHANISM OF ACTION:- 1.The mode of action of bradykinin -induced release/biosynthesis of prostaglandin E (PGE) was investigated using the method of the isolated perfused rabbit ear. 2.Phentolamine (1 μg /ml) hardly reduced the total amount of PGE released by bradykinin. Only in the first fraction (3 min) following bradykinin injection was PGE release significantly inhibited. 3.Papaverine (5–10 μg/ml) did not affect the bradykinin- induced PGE release but totally abolished the v...