ALUMINIUM HYDROXIDE BRAND NAME:-ALUDROX 0.84 g tab , 0.6g/ 10ml susp. Aluminium hydroxide gel . It is a bland,weak and slowly reacting antacid. On keeping it slowly polymerizes to variable extents into still less reactive forms . Thus, the ANC of a preparation gradually declines on storage. Also , the product from different manufacturers may have differing ANCs; usually it varies from 1-2.5mEq/g .Thus ,5ml of its suspension may neutralize just 1 mEq HCL . As such, little worthwhile acid neutralization is obtained at conventional doses. The A1³+ ions relax smooth muscle. Thus ,it delay gastric emptying. Alum.hydrox. frequently,causes constipation due to its smooth muscle relaxant and mucosal astringent action. Aluminium hydroxide binds phosphate in the intestine and prevent its absorption -- hypophosphatemia occurs on regular use. This may:(a) cause osteomalacia (b) be used therapeutically in hyperphosphatemia and phosphate stone. Small amount of Al³+ that is absorbed is excr...
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