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 AMIODARONE BRAND NAME:- CORDARONE,ALDARONE,EURYTHMIC 100,200mgtabs,150mg/3ml inj. AMIODARONE it is a antiarrhythmic  & cardiovascular drug. This unusual iodine containing highly lipophilic long-acting antiarrhythmic drug exerts multiple action: •Prolongs APD and Q-T interval attributable to block of myocardial delayed rectifier K+ channels . This also appears to reduce non-uniformity of refractoriness among different fibres. •Preferentially blocks inactivated Na+ channels (like lidocaine) with relatively rapid rate of channel  recovery: more effective in depressing conduction in cells that are partially depolarized or have longer APD. •Partially inhibits myocardial Ca²+ channels ,has noncompetitive beta adrenergic blocking property and alters thyroid function. Thus AMIODARONE is a multi-channel blocker with some additional activities. Conduction is slowed and ectopic automaticity is markedly depressed, but that of SA node is only slightly affected. Effect of oral dos...