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 AMPHOTERICIN B (AMB) BRAND NAME:-FUNGIZONE OTIC 3% ear drops .FUNGIZONE INTRAVENOUS,MYCOL 50mg vial. , FUNGISOME (liposomal AMB ) 10mg ,25mg, 50mg per vial inj; AMPHOLIP 10mg /2ml , 50mg / 10ml, 100mg/20ml inj. AMPHOTERICIN are the drug used for superficial and deep fungal infection. It is an antifungal antibiotics or it is obtained from streptomyces nodosus. CHEMISTRY AND MECHANISM OF ACTION:- The polyenes possess a macrocyclic ring ,one side of which has several  conjugated double bonds and is highly lipophilic, while the other side is hydrophilic with many OH   groups. A polar aminosugar and a carboxylic acid group are  present at one  end in some . They are all insoluble in water and unstable in aqueous medium. The polyenes have High affinity for ergosterol present in fungal cell membrane. They combine with it, get inserted into the membrane and several polyenes molecules together Orient themselves in such a way as to form a 'micropore' . The hydrophil...