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 APREPITANT BRAND NAME:- APRECAP, APRESET ,APRELIFE ,EMPOV 125mg (one cap) + 80mg (2caps) kit. APREPITANT is a medication used to manage and treat chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). It is in the neurokinin-1 antagonist class of medications.  PHARMACOLOGY & MECHANISM OF ACTION:-  It is a recently introduced selective , high affinity NK1 receptors antagonist that blocks the emetic action of substance P, with little effect on 5 HT3 and D2 or other receptors. Gastrointestinal motility is not affected. Oral aprepitant (125 mg + 80 mg + 80 mg over 3 days) combined with standard i.v. ondansetron+ dexamethasone regimen significantly enhanced the antiemetic efficacy against high emetogenic cisplatin based chemotherapy. Greater additional protection was afforded against delayed vomiting than against Acute vomiting. It was particularly useful in patients undergoing multiple cycles of chemotherapy. Adjuvant benefits of ap...