webmedi.blogspot.com

 BENZNIDAZOLE  Brand name:- Unkown BENZNIDAZOLE is a trypanocidal agent used to treat Chagas disease. Benznidazole was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to benznidazole, but further studies are needed.  Pharmacodynamic:-  Benznidazole is a trypanocidal agent which kills the causative organism in Chagas disease, Trypanosoma cruzi .Benznidazole is a nitroimidazole antiparasitic with good activity against acute infection with Trypanosoma cruzi, commonly referred to as Chagas disease. Like other nitroimidazoles, benznidazole's main mechanism of action is to generate radical species which can damage the parasite's DNA or cellular machinery.  MECHANISM OF ACTION:- Benznidazole is thought to be reduced to various electrophilic metabolites by nitroreductases present in Trypanosoma cruzi 1. These metabolites likely bind to proteins, lipids, DNA, and RNA resulting in damage to these ...