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Know details learn about DACARBAZINE ( DTIC) ?


DACARBAZINE  (DTIC)

Brand name:- Dacarin 100, 200 , 500mg injection; Dacarzine 200mg/ vial injection.

Dacarbazine, also known as imidazole carboxamide and sold under the brand name Dacarin , is a chemotherapy medication used in the treatment of melanoma and Hodgkin's lymphoma. For Hodgkin's lymphoma it is often used together with vinblastine, bleomycin, and doxorubicin. It is given by injection into a vein.

Pharmacodynamic:- 

Dacarbazine is a synthetic analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). After intravenous administration of dacarbazine, the volume of distribution exceeds total body water content suggesting localization in some body tissue, probably the liver. Its disappearance from the plasma is biphasic with initial half-life of 19 minutes and a terminal half-life of 5 hours.  In a patient with renal and hepatic dysfunctions, the half-lives were lengthened to 55 minutes and 7.2 hours.  The average cumulative excretion of unchanged DTIC in the urine is 40% of the injected dose in 6 hours. DTIC is subject to renal tubular secretion rather than glomerular filtration. At therapeutic concentrations dacarbazine is not appreciably bound to human plasma protein.

Mechanism of action:- 

Dacarbazine is activated by liver microsomal enzymes to monomethyl triazeno imidazole carboxamide (MTIC), which is an alkylating compound. It causes methylation, modification and cross linking of DNA, thus inhibiting DNA, RNA and protein synthesis.

Used:-

Used to treat cancer of the lymph system and malignant melanoma (a type of skin cancer). It may also be used to treat other kinds of cancer.

 Side effects:- 

This medicine often causes nausea, vomiting, and loss of appetite. The injection may also cause a feeling of burning or pain. However, it is very important that you continue to receive the medicine, even if you have discomfort or begin to feel ill. After 1 or 2 days, your stomach upset should lessen

Dose:-  3.5mg / kg / day i.v. for 10 days , reapat after 4 weeks, as directed by your doctor.

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