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 BISHYDROXYCOUMARIN ( DICUMAROL) BRAND NAME:- DICOUMAROL 50mg tab. BISHYDROXYCOUMARIN ( DICUMAROL ) is a naturally occurring anticoagulant drug that depletes stores of vitamin K (similar to warfarin, a drug that dicoumarol inspired) , and is slowly and unpredictably absorbed orally. Its metabolism is dose dependent — t½ is prolonged at higher doses. Has poor g.i. tolerance; not preferred now. PHARMACODYNAMIC:- Dicumarol is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X).   MECHANISM OF ACTION:- Like all 4-hydroxycoumarin drugs it is a competitive inhibitor of vitamin K epoxide reductase, an enzyme that recycles vitamin K, thus causing depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes. These compounds are not antagonists of Vita...