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 BRIMONIDINE BRAND NAME:- ALPHAGAN-P ,BRIMODIN - P 0.15% eye drops,IOBRIM 0.2% eye drops. BRIMONIDINE is clonidine congener is more an alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea.  PHARMACODYNAMIC:- This clonidine congener is more an alpha2 selective and more lipophilic than apraclonidine. It lowers i.o.t. by 20-70% by reducing aqueous production and by increasing uveoscleral flow. Peak effects on i.o.t. occurs after 2 hours . Allergic conjunctivitis and other ocular side effects are similar to but less frequent than with apraclonidine. Because of weaker an alpha1 action, side effects like mydriasis,eyelid retraction, conjunctival blanching followed by hyperemia are less prominent, but dry mouth, sedation and a small fall in BP have been noted. BRIMONIDINE is indicated both for short - term (prophylaxis of i.o.t. spikes post laser / post surgery) as well as long - term use in Glaucoma. It is generally used fo...