webmedi.blogspot.com

 ACETAMINOPHEN (PARACETAMOL) BRAND NAME:-CROCIN 500,1000mg tabs; METACIN,PARACIN 500mg tab, 125mg/5ml syrup,150mg/ml paed. Drops,ULTRAGIN, PYRIGESIC ,CALPOL 500mg tab,125mg tab,125mg/5ml syrup, Paracetamol rectal suppository 80,170mg. And other many brands available in India. PARACETAMOL (acetaminophen) is a para-amino  phenol derivatives, analgesic, good antipyretic and weak anti-inflammatory action.  MECHANISM OF ACTIONS:-  The central analgesic action of Paracetamol is like aspirin,i.e. it raises pain threshold,but has weak peripheral anti-inflammatory components. Analgesic action of aspirin and Paracetamol is additive. Paracetamol is a good and promptly acting antipyretic. It is a poor inhibitor of PG synthesis in peripheral tissues,but more active on COX in the brain. One explanation offered for the discrepancy between it's analgesic -antipyretic and anti-inflammatory action is its inability to inhibit COX in the presence of peroxide which are generated at sites...