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 BUTAMBEN BRAND NAME:- CETACAINE  BUTAMBEN is local anesthesia of mucus membranes other than the eyes.  PHARMACODYNAMIC:- Butamben has been shown to selectively inhibit dorsal root pain signal transmission for periods of months when administered as epidural suspensions.1 The effect of butamben is not related to any significant loss of motor function which indicates that it targets specifically the pain-sensing C fibers of the dorsal root.3 When administered topically, butamben produced anesthesia by accumulating in the nerve cell membrane causing it to expand and lose its ability . MECHANISM OF ACTION:- Butamben acts by inhibiting the voltage-gated calcium channels in dorsal root ganglion neurons.2 The modification in this channels is thought to cause a disturbance of the channel kinetics acceleration.1 It is reported as well that butamben is an inhibitor of the sodium channels and a delayed rectifier of potassium currents. All the effects of butamben are performed in the...