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Showing posts with the label Alogliptin and metformin

ALOGLIPTIN

 ALOGLIPTIN BRAND NAME:-VIPIDIA & many brands available in INDIA ALOGLIPTIN is  an oral  anti-diabetic drug  in the  DPP-4 ( dipeptidyl peptidase-4 )  inhibitor  (gliptin) class. Alogliptin does not decrease the risk of heart attack and stroke. Like other members of the gliptin class, it causes little or no weight gain, exhibits relatively little risk of hypoglycemia, and has relatively modest glucose-lowering activity. Alogliptin and other gliptins are commonly used in combination with metformin in people whose diabetes cannot adequately be controlled with metformin alone. MECHANISM OF ACTION:- Alogliptin inhibits dipeptidyl peptidase 4 (DPP-4), which normally degrades the incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon like peptide 1 ( GLP-1). The inhibition of DPP-4 increases the amount of active plasma incretins which helps with glycemic control. GIP and GLP-1 stimulate glucose dependent secretion of insulin in pancrea...