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 Chloroquine(CQ)  Brand name:- Resochin, cloquin, lariago,Nivaquin-p 250mg tab. Chloroquine is an antiparasitic medication that treats malaria. It works by increasing the levels of haeme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading. Pharmacodynamic:-  Chloroquine inhibits the action of heme polymerase, which causes the buildup of toxic heme in Plasmodium species. It has a long duration of action as the half life is 20-60 days.10 Patients should be counselled regarding the risk of retinopathy with long term usage or high dosage, muscle weakness, and toxicity in children. Pharmacokinetics:-  Oral absorption of CQ is excellent. About 50% gets bound in the plasma. It has high affinity for melanin and nuclear chromatic: gets tightly bound to these tissue constituents and is concentrated in liver , spleen, kidney,lungs (several hundred -fold), skin , leucocytes and some other tissues. It's selectiv...