webmedi.blogspot.com

 AMANTADINE BRAND NAME:-AMANTREL,NEAMAN ,COMANTREL 100mg tab. AMANTADINE as an antiviral drug for prophylaxis of influenza A2, and Glutamate (NMDA -RECEPTOR) ANTAGONIST (DOPAMINE FACILITATOR ) class of drug . PHARMACODYNAMIC & MECHANISM OF ACTION:- it was found serendipitiously to benefit parkinosonism. It acts rapidly but has lower efficacy than levodopa , which is equivalent to or higher than ANTI- cholinergic. About 2/3rd patients derive some benefit. However, tolerance develops over months and the efficacy is gradually lost.  Amantadine promotes presynaptic synthesis and release of DNA  in the brain and has anticholinergic property. These were believed to explain all its beneficial effects in Parkinosonism. However,an antagonistic action on  NMDA type of glutamate receptors, through which the striatal dopaminergic system exerts its influence is now considered to be more important. CHEMICALLY,it is unique Tricycle amine unrelated to any nucleic acid precursor,...