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ABCIXIMAB BRAND NAME:- REOPRO 2mg /ml inj . ABCIXIMAB is nonantigenic ,antiplatelet and antithrombotic drugs . These are the drug which interfere with platelet function and are useful in the prophylaxis of thromboembolic disorders. PHARMACOLOGICAL & MECHANISM OF ACTION:- It is the Fab fragment of a chimeric monoclonal antibody against GPIIb/IIIa, protein,but is relatively nonspecific and binds to some other surface proteins as well. Given along with Aspirin+ heparin during PCI it has markedly reduced the incidence of restenosis, subsequent MI and death. In the ISAR-REACT2 trial addition of ABCIXIMAB to clopidogrel(600mg oral loading dose) for PCI in high risk ACS patients, reduced ischaemic events by 25%. After a bolus dose, platelet aggregation remain inhibited for 12-24hr, while the remaining antibody is cleared from blood with a t½ of 10-30min. PRECAUTIONS:- ABCIXIMAB is nonantigenic. The main risk haemorrhage, incidence of which can be reduced by carefully managing the concomit...